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We adjusted observations that were generated in subpopulations, because it was the only significant bias covariate identified by the bias covariate selection algorithm (Supplementary Table 7)

JUUL, an e-cigarette device launched in 2015 that resembles a USB drive, has become especially popular among teens and young adults as it can be used discreetly, has a high nicotine content, and comes in flavors such as mint, mango and fruit

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From a compliance standpoint, readers should know that results vary depending on the user's habits, expectations, and willingness to incorporate CAPNOS into a broader lifestyle change

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